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| Newscast | Time/Day |
| Monday – Friday | |
| News10NBC Today | 4:30 a.m. – 7 a.m. |
| News10NBC at Noon | 12 p.m. – 12:30 p.m. |
| News10NBC at 4 | 4 p.m. – 5 p.m. |
| News10NBC at 5 | 5 p.m. – 6 p.m. |
| News10NBC at 6 | 6 p.m. – 6:30 p.m. |
| News10NBC at 7 | 7 p.m. – 7:30 p.m. |
| News10NBC at 11 | 11 p.m. – 11:30 p.m. |
| Saturday | |
| News10NBC Today | 6 a.m. – 7 a.m. |
| News10NBC Today | 8 a.m. – 9 a.m. |
| News10NBC at 6 | 6 p.m. – 6:30 p.m. |
| News10NBC at 11 | 11 p.m. – 11:30 p.m. |
| Sunday | |
| News10NBC Today | 6 a.m. – 8 a.m. |
| Rochester In Focus | 10 a.m. – 10:30 a.m. |
| News10NBC at 6 | 6 p.m. – 6:30 p.m. |
| News10NBC at 11 | 11 p.m. – 11:30 p.m. |